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Migrastat (Sumatriptan)
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Sumatriptan

Migrastat comes as a spray (Imitrex, Tosymra) to inhale through the nose. It also comes as a powder (Onzetra Xsail) to inhale through the nose with a breath-powered delivery device. It is usually used at the first sign of a migraine headache. If your symptoms improve after you use Migrastat but come back, you may use a second dose of Migrastat (Imitrex, Onzetra Xsail) at least 2 hours later, or a second or third dose of Migrastat (Tosymra) at least 1 hour after each other, if needed. However, if your symptoms do not improve after you use Migrastat, do not use a second dose without talking to your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Migrastat exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

You may use your first dose of Migrastat nasal in a doctor's office or other medical facility where you can be monitored for serious reactions.

Call your doctor if your headaches do not get better or occur more frequently after using Migrastat nasal.

If you use Migrastat more often or for longer than the recommended period of time, your headaches may get worse or may occur more frequently. You should not use Migrastat nasal or take any other headache medication for more than 10 days per month. Call your doctor if you need to use Migrastat nasal to treat more than four headaches in 1-month period.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

To use the nasal spray, follow these steps:

  1. Read all of the manufacturer's instructions for using the nasal spray before you use your first dose.
  2. Blow your nose gently.
  3. Remove the device from the blister pack.
  4. Hold the sprayer between your fingers and thumb, but be careful not to press the plunger.
  5. Use your other hand to block one nostril by pressing firmly on the side of your nose.
  6. Put the tip of the sprayer into your other nostril as far as feels comfortable (about one half inch). Keep your head upright and close your mouth. If you are using Tosymra, tilt your head slightly back, and point the tip of the inserted sprayer toward the outside of your nose. Be careful not to press the plunger or spray the medication in your eyes.
  7. Breathe in gently through your nose. At the same time, press the plunger firmly with your thumb.
  8. Keep your head level and remove the tip from your nose.
  9. Breathe gently in through your nose and out through your mouth for 10 to 20 seconds. Do not breathe in deeply. It is normal to feel liquid in your nose or the back of your throat.
  10. The sprayer only contains one dose of medication. After you have used it, dispose of it safely, so that is out of the reach of children and pets.

To inhale the nasal powder using an inhaler, follow these steps:

  1. Read all of the manufacturer's instructions for using the nasal device before you use your first dose.
  2. Remove the nosepiece from the pouch. The nosepiece contains a capsule filled with Migrastat powder.
  3. Click the nosepiece into the device body.
  4. Fully press and release the white piercing button on the device body one time to pierce the capsule inside the nosepiece. It should only be pressed once.
  5. Insert the first nosepiece deeply into the nostril. Keep it in the nostril as you rotate the device to put the mouthpiece into the mouth.
  6. Blow forcefully with your mouth into the device for 2 to 3 seconds to deliver the medication into the nose. You may hear a vibration or rattling noise as you do this. Do not hold or press the white button while blowing.
  7. Press the clear tab to remove the first nosepiece. Check the capsule in the nosepiece to ensure that the medication was given.
  8. Remove and discard the nosepiece safely, so that is out of the reach of children and pets.
  9. Repeat steps 2 to 8 using a second nosepiece in the other nostril to give the total dose.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other names for this medication:
Sumatriptan, Imitrex, Amigrenex, Amigrenin, Cinie, Forcet, Formigran, Imigran, Imigrane, Imiject, Migranol, Migrastat, Migrex, Nograine, Sitran, Suma, Sumagen, Sumamigren, Sumatab, Sumatran, Sumetrin, Sumigran, Suminat, Sumitran, Sumitrex, Suvalan, Zumo,

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Using the minimally invasive PCCP technique in unstable pertrochanteric femur fractures provides a promising therapy option especially with regard to surgical time, radiographic screening time and failure rate. When the position of the stereogenic center was changed with respect to the stereocontrolling moiety, an odd-even effect was found. These results suggest a modulation of intracortical activation of the dentate gyrus by cholecystokinin, and that this action is probably mediated by a central-type receptor.

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Therefore, concurrent administration of these agents may induce prolonged muscle paralysis via synergistic interaction. No N1 changes were seen for the subjects receiving 70--90 mg/day or the control subjects. DESIGN CONCEPTS FOR A COMPREHENSIVE COMMUNITY MENTAL HEALTH CENTER. In order to study putative hypothalamic mechanisms of sleep waking cycle regulation we destroyed, by electrolytic coagulation, a large part of the medial hypothalamus overlapping the paraventricular nucleus in 6 adult cats.

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How can such tasks be accomplished without being overly costly and time- and labor-intensive? Vascular anastomoses between the retina and choroid may occur in different congenital and acquired conditions. Narcolepsy with cataplexy associated with nocturnal compulsive behaviors: a case-control study. The trimer constitutes the basic structural unit of the 24 subunit oligomer. Implications for the practical musical and emotional training of music therapists are discussed.

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Beta-alanine containing cyclic peptides with predetermined turned structure. Multiple mesenteric well-differentiated (WD) liposarcoma is an extremely rare entity. ZO-1, E-cadherin and beta-catenin in the plasma membrane or membrane-cytoskeleton were either slightly reduced or unaffected by oxidative stress or genistein. This mRNA species could represent a tumor-specific CGM2 splice variant. The apical root end is generally removed with burs, and the adjacent periapical tissue curetted, or alternatively treated with ultrasound or laser.

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In this work we studied the effects of the lack of Bcl2 in MCF7 cells. Toxicological implications for grey seals are limited, but the maximal PFOS concentration found in this study was about 40 times lower than the predicted lowest observed effect concentrations (LOEC). Regulated pre-employment medical examinations and their effect on the utilization of health services: the experience of 1,498 police cadets, Quebec, 1988. We also show that XMAP215 immobilized on polymer beads induces the formation of microtubule asters in egg extracts as well as in solutions of pure tubulin.

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An immunochemical method for detection of prostatic acid phosphatase is described. Point-of-care ultrasonography (POCUS) is often used to distinguish abscess from cellulitis in superficial soft tissue infections. The opinion survey included questions on pedagogical and education studies, teaching practice, research methods, statistics, related science and supporting studies. Eleven patients are described here with both RA and SLE, in whom the diagnoses were separated by one to 24 years.

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e19a2 BCR-ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases. In the Danish Health and Morbidity Survey carried out in 1987, 1994, 2000 and 2003, a total of 11,754 people aged 50 and older were asked about their alcohol consumption. Continuous 24-hour ocular dimensional profile recording in medically treated normal-tension glaucoma.

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All four practices identified problems needing attention in the older population, developed different projects focused on particular needs among older people, and tested them in practice. To evaluate the dynamic changes of optical quality in patients with dry eye disease (DED) by using a double-pass system. Prescribers with the highest amount paid for drugs in this class, and for which there was no appropriate diagnosis (intervention group), were provided with a list of the patients for whom they prescribed the drug for an off-label clinical condition. Constipation was not improved in two of five patients with preoperative paradoxic sphincter reaction. Hydroxyapatite block for reconstruction of severe dysplasia or acetabular bone defects in total hip arthroplasty: operative technique and clinical outcome.

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The highest intensity of EGF and EGFR immunoreaction in endothelial cells of the uterine artery was observed in the follicular phase. Use of prenatal diagnostic procedures in pregnancies affected with birth defects, Hawaii, 1986-2002. Reversible photoisomerization of the core diarylethene gave rise to a reversible morphological transformation between colorless microspheres and colored fibers. To study the trend in mortality from 1980 to 1991 in a cohort of 2432 intravenous drug users (IVDU) enrolled between 1 November 1980 and 31 December 1988.

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Two validated and standardized tests were given to the whole sample at the entrance of the study (T0) and after 6 months of treatment (T6): the Greene Climacteric Scale (GCS) and the Beck Depression Inventory (BDI). The authors consider some of the described alterations caused by continuous irradiation to act as compensatory mechanisms of the impaired cell. Feasibility of a 59Fe ferrokinetic study based on bone-marrow scans. The stimulatory effect of glucose on hormone-maintained protein synthesis cannot be explained by changes in the adenine nucleotides. Efficacy of oral and parenteral hyposensitization with pollen extracts

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Many infant deaths could be prevented by increasing birth weight through supplementary diet for mothers during pregnancy and other types of antenatal and postnatal care. The aim of this study was to investigate the incidence of cancer in a cohort of women attending a large infertility clinic in the UK. They were also more likely to select a colored filter to aid visual comfort, particularly colors in the blue-to-green sector of the spectrum. G-protein-coupled receptors (GPCRs) are important therapeutic targets for many areas of drug research and development.

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NPAC is a distinct entity in all types of nasopharyngeal carcinoma. We describe differences in the spatial distribution and conformation of these conjugated epitopes for the first time: a partially hidden benzylpenicilloyl and a more exposed amoxicilloyl. Results from neutralization-escape mutants and site-directed mutagenesis revealed that the 5E8 epitope is a highly conformation dependent epitope consisting of at least residues E330, E332 and E367 on the domain III.

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In particular, an investigation of the three-dimensional architecture was conducted using scanning electron microscopy. Due to the manufacturing processes involved, these porous materials are most often geometrically anisotropic on a microscopic scale, and for demanding applications, there is a need for improved characterization methods. Rapid, safe discharge home for this large group is hampered by clinical uncertainty. OBSERVATIONS OF COMPLICATIONS OCCURRING IN GOUT PATIENTS DURING TREATMENT

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Broad subdivisions were distinguishable by pulsed-field gel genomic digest patterns, but they did not allow subspecific or phenotypic distinctions. A technique that combines scanning electrochemical microscopy (SECM) and scanning optical microscopy (OM) was developed. Conditionally immortalized murine calvarial (CIMC) cells that support differentiation of precursors into mature osteoclasts were isolated. Producing minimal side effects is the goal of any clinical procedure. In the few existing reports, evolution was generally fatal, especially in immunocompromised patients, despite treatment with antifungal drugs and antibiotics.

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Mental flexibility, memory, and information-processing speed may be particularly vulnerable in the aging brain. Phylogenetic analysis of canine parvovirus CPV-2 strains and its variants isolated in Poland. Fra(2)(q13) was detected in one healthy sib of one of the probands. Disruption of the middle hepatic vein is not crucial for liver regeneration of the remnant liver after right hemihepatectomy for hepatic tumors. Age also related to differences between future expectations and present quality of life estimates.

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