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Effects of macrocyclic ring size and substituents on the aromatic linker. When it is bound to the receptor complex, cortisol binds with lower affinity and nuclear translocation of the receptor is less efficient. As the age of the female patient increased, beginning at age 30, the cumulative spontaneous conception rate decreased. With the advent of environmental scanning electron microscopy (ESEM), insulating materials can now be examined without the need for conductive coatings to be applied.

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Knockdown of three of the newly identified miRNAs results in altered root growth phenotypes, confirming that novel miRNAs predicted by PIPmiR have functional relevance. We report successful endoscopic placement of a left internal mammary artery bypass graft to the left anterior descending artery using the daVinci robotic system in a patient with a severely reduced left ventricular ejection fraction. Evaluation of improved zirconyl hematoxylin compared to the classical pH 2.5 Alcian blue method for demonstrating acid mucins.

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X-ray microanalysis was performed on rat mast cells prepared by quick-freezing, cryosectioning and freeze-drying (QF-FD) method, or quick-freezing and freeze-substitution (QF-FS) method. Diagnosis and management of non-erosive reflux disease--the Vevey NERD Consensus Group. Recurrent aphthous stomatitis and oral lichen planus are the mucosal diseases of unknown cause seen most frequently in dental practice, and the most likely mucosal diseases for which a dentist will prescribe.

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In yeast and human mitotic cells, a similar regulatory network restrains these nuclease activities until mitosis, biasing the outcome of recombination toward noncrossover products while also ensuring the elimination of any persistent joint molecules. Here, we highlight exciting findings and promising approaches in the recent literature in which researchers integrate advanced micro-engineering, design, and analytical strategies to improve the relevance and utility of high-throughput screening in the drug discovery pipeline.

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aeruginosa was significantly higher among in-patients who required continual care than those in need of partial care, while the detection rate of MRSA was significantly higher among in-patients with low serum albumin than those with normal serum albumin. FH-deficient cancers depend on ABL1-mediated metabolic adaptation. Chemical systems that are far from thermodynamic equilibrium may form complex temporal and spatiotemporal structures. EXPERIMENTAL AND CLINICAL STUDIES WITH ETHACRYNIC ACID, A CHEMICALLY NEW DIURETIC The trajectory of neuropsychological dysfunctions in bipolar disorders: a critical examination of a hypothesis.

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The lectin activity of wheat germ agglutinin on human red cells was not affected by the amines indicating that the amines probably acted on platelets and not on the agglutinin. The tumorigenicity of dexamethasone-treated tissue-cultured mammary tumor cells was compared to that of untreated mammary tumor cells. The cell lines have retained a diploid karyotype, display no abnormalities, and are able to grow in a polar mode.

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Cdc2 phosphorylates Pak1 at the identical site in vitro, and inhibition of Cdc2 abolishes Pak1 mitotic phosphorylation in vivo, indicating that Cdc2 is the kinase responsible for phosphorylating Pak1 in mitotic cells. Removal of foreign bodies from the upper segment of the digestive tract using an endoscope Indeed trends in these regions compared with those for the rest of Scotland support the benefit of cervical screening. Modification of force-interval relations during early adaptation to pressure overload in dogs.

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Adolescent CIE-treated subjects did not exhibit this age-related increase in sensitivity. Pulse height spectra (PHS) of the charge produced per x ray were recorded for monoenergetic 30.9, 49.4, and 73.8 keV x-ray sources. Radioactive stents have been proposed as endovascular irradiation device to prevent in-stent restenosis by inhibiting neointimal proliferation. These data are consistent with the hypothesis that formation of the 5,6-epoxide of quinoline is associated with its metabolic activation to a tumorigen. This effect was particularly manifested among brain regions that are typically involved in cerebral modulation of respiration.

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The proteins plakophilin-2 (PKP-2) and connexin43 (Cx43) are components of desmosomes and gap junctions, respectively. They have a linear response up to flows of 6, 10, 12, and 28 ml X s-1, respectively, that correspond to 100 ml X s-1 X kg-1 or more, depending on the body size of the animals (15-350 g) in which they could be used. Compared to sucrose-unpaired training, repeated association with sucrose established the light-tone stimulus as a robust conditioned reinforcer. Respiratory complications usually occur in high-risk clinical settings that are not eligible for outpatient surgery. BENIGN ESOPHAGEAL STRICTURE AND THE LOWER ESOPHAGUS LINED BY COLUMNAR EPITHELIUM: REPORT OF TWO CASES.

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Adeno-associated virus is the most promising viral vector system for the treatment of respiratory disease because it has natural tropism for airway epithelial cells and does not cause any human disease. National initiatives are underway to use trained professionals, physicians and others, to act as community sentinels to uncover and help unknown victims.

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This paper describes the procedures used for the analysis of a variety of processed dried foods for volatile nitrosamines and reports the results obtained. The model adequately described the uptake of trifluralin and lindane into ryegrass by providing the first-order rate constants of uptake, release, transpiration, and metabolism and formation of bound residues.

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Its hardware and software allows communication over the Internet with the central station, interpretation of commands from the central station, and conversion of the commands into mechanical and nonmechanical actions at the remote location, which are communicated back to the central station over the Internet. Accordingly, we hypothesized that MK3 could have significant effects only in an MK2-free background and generated MK2/MK3 double-knockout mice. Small intestinal mucositis is a common side-effect following high-dose chemotherapy, causing patients to experience pain and abdominal complications often leading to extended stays in hospital. The reported results show that excited state dipole moment is greater than ground state dipole moment, which indicates that the excited state is more polar than the ground state.

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The core concepts and methods in human ergology research such as promoting real work life studies, relying on positive efforts of local people (daily life-technology), promoting active participation of local people to identify practical solutions, and learning from local human networks to reach grassroots workplaces, have provided useful viewpoints to devise such participatory training programmes. This study demonstrated that the modified-live bovine viral diarrhea virus (BVDV) type 1 and 2 fractions of a multivalent vaccine protected pregnant heifers and their fetuses against virulent BVDV types 1 and 2 challenge exposures at 370 days after vaccination.

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Tuberculosis recurrence and mortality after successful treatment: impact of drug resistance. Tungsten treatment had no effect on plasma lipids but lowered the plasma XO activity. The analysis demonstrated that rates of perinatal mortality associated with extremely long or extremely short birth intervals in women at high reproductive risk due to pre-pregnancy nutritional status, obstetrical or chronic degenerative pathology, or reproductive pattern were much higher than in low risk births. The glomerular function thereby adapts to an insufficient tubular function, without there necessarily being any structural changes in the glomeruli.

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TVM induction is a male F344 rat-specific event, and chemicals/agents that induce only TVM in the male F344 rat from a typical two-sex rat and mouse chronic bioassay are likely irrelevant in human risk assessment. H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 (demorphin), and opiate-like peptide, and tri-, tetra-, penta- and hexapeptide-amide analogs, were synthesized by conventional methods in solution, to determine the minimum peptide chain-length, required for analgesic activity. We demonstrate that yeast Kre33 and human NAT10 are RNA cytosine acetyltransferases with, surprisingly, specificity toward both 18S rRNA and tRNAs. A large solid sponge-like tumor with multicystic areas throughout, in which there were some small hemorrhagic spots, was shown on magnetic resonance (MR) imaging. Phenylalanine has no effect on dihydropteridine reductase activity in phenylketonuria fibroblasts.

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Comparison of cases diagnosed over the 20 years of this study suggest that cicatricial RLF in recent years is less likely to result in severe visual disability. The highest levels of CEA (above 1,000 ng/ml) were found in samples from patients with gastrointestinal carcinomas, while negative results were most often found in lymphoreticular and ovarian malignancies. The deprotonation of the enol form of acetylacetone by the amine of the catalyst is found to occur easily, leading to an ion pair characterized by multiple H-bonds involving the thiourea unit as well.

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The relationships between (i) urinary free cortisol and urinary creatinine concentrations and (ii) the urinary cortisol/creatinine ratio (UCCR) and various glycaemic levels were studied in three groups--normal, insulin-stressed and insulin-treated diabetic subjects. Current but not past smoking increases the risk of cardiac events: insights from coronary computed tomographic angiography. Humans and rabbits appear to react to certain genus-specific antigens present in Pogonomyrmex whole body extracts. Disturbances in the glutathione/ophthalmate redox buffer system in the woodchuck model of hepatitis virus-induced hepatocellular carcinoma. When public health nurses determined that recipients required health consultation regarding lifestyle from the health checkup, they consulted with the recipients regarding improvement of lifestyle.

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Treatment of pulmonary artery occlusion attributable to mediastinal fibrosis can be challenging. However, the effects of exercise therapy on cardiovascular function of these patients have been poorly studied.

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BrMET1a was expressed in vegetative and reproductive organs, while BrMET1b was expressed only in pistils, indicating that these two genes have different functions. The effect of a single remote course versus weekly courses of antenatal corticosteroids on functional residual capacity in preterm infants: a randomized trial. Statistical analysis, demonstrated the healing rates of the two groups to be statistically different.

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LIPID ALTERATIONS OCCURRING IN MICROSOMES DURING THE ENZYMIC OXIDATION OF TPNH. An anaerobic film-pouch method has been developed for the isolation and enumeration of clostridia.

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The target tumor mass was reduced in size, occult blood vanished, and the tumor marker was reduced. Acute encephalopathy after initiation of cranial irradiation for meningeal leukaemia. Gene expression for TRFs and TIN2 was studied in hematopoietic cell lines, blood or bone marrow cells from acute leukemia and in normal leukocyte fractions. The technique of post-coital transection of the oviducts from the uterus at various intervals after mating has been used to establish how soon a population of spermatozoa competent to fertilize the egg(s) first appears in the oviduct of the ewe.

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Prompt administration of Crimean-Congo hemorrhagic fever (CCHF) virus hyperimmunoglobulin in patients diagnosed with CCHF and viral load monitorization by reverse transcriptase-PCR. Total hip replacement may have a larger role in the treatment of displaced femoral neck fractures than it has in the past. CHANGES IN SPONTANEOUS ACTIVITY AS A MEASURE OF SENSITIVITY TO ROTATION IN THE WHITE RAT.

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Typical findings were ectasy or aneurysm formation of the ascending aorta, hypoplastic aortic arch, ectasy or aneurysm formation of the supraaortic vessels, circumscript aneurysm of the descending aorta at the side of surgery, restenosis of the descending aorta and malformations and anomalies of arterial vessels. Radiotherapy was given to both patients and follow-up has failed to reveal neoplastic disease 4 and 3 years, respectively, after the diagnosis.

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Forty patients who underwent cardiac surgery and cryoablation guided by epicardial mapping data to eliminate AF originating from the left atrium were included in this study. Effect of danshensu on activation of JNK pathway in hepatic stellate cells(HSCs) induced by IL-1 beta

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Using PFGE, complete separation of the full components of the genome was not attained, due to the limited resolution of large chromosomes, but 5-12 chromosomes with sizes of 0.6-5.7 Mbp were resolvable for every strain. Autonomic dysfunction is common in patients with chronic liver disease, but it is still unclear whether acute hepatitis coincides with alterations in autonomic functions. The patient was transferred to the urological department for further cytoreductive therapy. Although SKF 38393 did not influence the latency of postcopulatory departures, incomplete departures occurred in five out of eight males.

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Extrapolations of these in vitro data to the interpretation of PET images should be made with caution since tumors may have confounding factors that may affect in vivo tracer uptake. We determined that the same phenomenon occurs in non-genetically altered mice: LSO neurons were 5-HT-immunoreactive at postnatal days 1 and 8. This study investigated the value of a sensitive method for detecting infectious HIV in semen for use as a marker for infectivity.

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In addition, OTR4131 was well tolerated, and the combination of amifostine and OTR4131 further enhanced mucosal protection. Super-resolution optical microscopy of lipid plasma membrane dynamics. Future studies are needed to validate this index in varied populations and test its use in the clinical setting. Significance of a fall in serum CEA concentration in patients treated with cytotoxic chemotherapy for disseminated colorectal cancer. Three clinical end points were studied: all-cause mortality, cardiovascular mortality, and cardiovascular events.

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STUDIES ON THE PRACTICAL CLINICAL APPLICATION OF THE DYE DILUTION METHOD. Solid ovarian masses in children are considered malignant unit proven otherwise. Preparation of a rabbit anti-guinea pig basophil serum: in vitro and in vivo characterization. Excellent 3-year results following living-donor kidney transplantation and tacrolimus immunosuppression in Japan. Characterization of lymphoid cell lines established from multiple Epstein-Barr virus (EBV)-induced lymphomas in a cotton-topped marmoset.

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Industrial production of enzyme-modified wool fibers for machine-washable bed coverings. However, it is not known whether unique intensity coding mechanisms exist for specific modalities or whether a common, centralized magnitude estimator operates for all sensations.

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We studied time-dependent coding of cortical and spinal neurons in primates performing an isometric wrist task with an active hold period, which made it possible to segregate motor behavior into its phasic and sustained components. Pulmonary artery banding for retraining was performed in 23 cases.

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We have shown that the effect of the solvent slows down the dynamics to the experimentally observed time scales. on the lens involve fluorescent chromophore formations, pigmentation, and interferes with synthesis of lens proteins, catalyse insoluble proteins. We present a case of obscure gastrointestinal bleeding associated with a large pseudoaneurysm in the splenic artery after simultaneous kidney-pancreas transplantation. These websites were examined using thematic content analysis, which included identifying informational themes, generating frequency counts of these themes, and comparing trends in these counts to the established literature.

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Preclinical evaluation of a replication-deficient intranasal DeltaNS1 H5N1 influenza vaccine. Genetic analysis of dopaminergic system development in zebrafish. However, mites surviving 1, 3, and 5 days after treatment were viable and infective when transferred to untreated cattle. THE CLINICAL PRACTICAL USE OF PROTEIN ANABOLIC STEROIDS AND THEIR MECHANISM OF ACTION WITH SPECIAL REFERENCE TO PROTEIN ANABOLIC EFFECTS

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Secondary metabolites ranging from furanone to exo-polysaccharides have been suggested to have anti-biofilm activity in various recent studies. ESTIMATION OF HELICITY OF PROTEINS FROM OPTICAL ROTATION DISPERSION MEASUREMENTS. XLRS could be manifested as massive hemorrhage inside or outside of the schisis cavity early in infancy. Full length POMC was mutated by deleting amino acids 2-26 from the N-terminal region. These findings are, however, not universally accepted and there exists certain controversy regarding the potential benefits of vitamin D.

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The lameness was shown to be due to a myopathy affecting muscles deep to the gastrocnemius. The pituitary glycoprotein hormones, LH and FSH, and their receptors are essential for normal reproductive function in both sexes.

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Thus, tyrosine phosphorylation of APP may functionally link APP processing and neurotrophic signaling to intracellular pathways associated with cellular differentiation and survival. These results indicate that allelic variants at the dopamine transporter locus do not provide major genetic contributions to the etiology of schizophrenia and related disorders in these pedigrees. It is remarkable that the standard deviation of the molecular weights of such pieces increases with age significantly, too.

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rodentium was transformed with the tetracycline resistance gene, tetO, and continuous oral administration of a non-therapeutic dose of chlortetracycline to mice did not affect densities of C. Vitamin D receptor, oestrogen receptor-alpha gene and interleukin-1 receptor antagonist gene polymorphisms in Hungarian patients with primary biliary cirrhosis. In half of our patients, relief lasted for up to 3 weeks with minimal side effects. We sought to describe the advantages of the retrosigmoid-transmeatal (RS-TM) approach in the application of auditory brainstem implants (ABIs) in adults with monolateral and bilateral vestibular schwannoma (VS) and in children with cochlear nerve aplasia. The presence of PCC was quantified as the number of frequencies where PCC is larger than zero across the sensorimotor area.