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Glycogen accumulation caused by DCA treatment was not hindered by inhibitors of extracellular-regulated protein kinase kinase (Erk1/2 kinase or MEK) or p70 kDa S6 protein kinase (p70(S6K)), but was completely blocked by the phosphatidylinositol 3-kinase (PI3K) inhibitors, LY294002 and wortmannin. The study of charge transport through increasingly complex small molecules will benefit from a detailed understanding of how contaminants from the environment affect molecular conduction. Metabolic syndrome has the highest prevalence among Mexican-American women. Substrate tunnels in enzymes: structure-function relationships and computational methodology.

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Strains bearing the areA::NC-GATA construct, which includes the sequence encoding both the N and C-terminal domains of GATA-1, leads to a pronounced increase in one of two AREA-dependent complexes and implicates the N-terminal domain of GATA-1 in mediating protein-protein interactions. Enlarged fasting antral area reflects increased volume of gastric juice. Symptom scores in the first 2 weeks after vaccination or treatment with placebo were used to calculate a baseline range for each patient.

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Patients should be assessed covering functional, physiological and socio-economic domains that identify significant comorbid disease and frailty, to ensure that planned chemotherapy is appropriate. In addition to lamina propria macrophages, endothelial cells, and spindle cells, intestinal epithelial cells are able to produce MCP-1. Immune system disorders were not associated with any of the other variables. The amount of language exposure is correlated with bilingual lexical development, but findings are mixed on how exposure relates to nonword repetition (NWR), a complex skill involving both short-term processing and long-term vocabulary knowledge. Our main findings were that static and dynamic stretch reflex thresholds were decreased in spastic hemiparetic compared to normal subjects and that the thresholds depended on velocity.

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Freeze-fracture replicas of stallion spermatozoa, collected from the proximal caput, corpus and cauda epididymides regions, were analyzed by electron microscopy to explore the distribution and density of intramembrane particles (IMP). By measuring the release of methanol as a function of treatment time, the rate of enzymatic pectin conversion was determined. An analysis of factors for the differential staining of sister chromatids in human chromosomes using Giemsa. Induction of micronuclei by 153Sm-EDTMP in peripheral blood lymphocytes of patients with bone metastases.

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Not all combinations of adhesive and composite resin by same manufacturers failed to show significantly higher bond strengths than mixed manufacturer combinations. Homocystinuria is a rare autosomal recessive disease complicated by early and aggressive occlusive arterial disease. However, for both static and dynamic extensor gamma-cells, excitation prevailed from both posterior biceps--semitendinosus and the gastrocnemius--soleus nerves, whereas inhibition was more frequent from the deep peroneal and quadriceps nerves.

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The method may be useful in development of maximum permissible concentration of azlocillin and its control in ambient air of production areas. The characteristic steady-state current was used to estimate the particle size. Situational-specificity of motivational differences between depressed and nondepressed subjects.

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The experimental plane crosses the constant position lines (the loci of all possible changes of the joint angles that correspond with an invariant position of the endpoint) at an acute angle. The patient was a 40-year-old human immunodeficiency virus antibody-positive male with hemophilia A. Its amino terminal domain is highly similar to the amino terminal, DNA-binding domain of STE12 of Saccharomyces cerevisiae. Finally, we tested the expression of EGFP-MgAtg9 in null mutants of MgATG1, 2, 13 and 18, respectively.

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Specificity or affinity of cytotoxic T cells for self H-2K determinants apparently does not change between primary and secondary responses to ectromelia virus infection. Moreover, it may be worthwhile to try new successful applications demonstrated in adults for paediatric anaesthesia. The best characterized T4SS are the type IVA systems, which exhibit extensive similarity to the Agrobacterium VirB T4SS.

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In this article we report on the relative validity of the FFQ instrument modified to estimate intake of N-nitroso compounds. To evaluate the accuracy of high-frequency sonography on pretherapeutic T-staging in patients with laryngeal carcinoma.

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As a result, cessation, decreasing the dose or changing the type of ICS may trigger features of adrenal insufficiency (AI). These four tannins were determined from spectrometric and chemical evidence to be the ellagic C-glucosyl tannins vescalagin, castalagin, stachyurin and casuarinin.

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Omega-3 fatty acids, which are abundant in fish oil, improve the prognosis of several chronic inflammatory diseases although the mechanism for such effects remains unclear. Controversy clarified: an updated review of clinical psychology and tele-health. Diameters were recorded at transmural pressures of 60 and 120 mmHg during superfusion with physiologic saline containing 5 mm D-glucose, 20 mm D-glucose, or 5 mm D-glucose and 15 mm L-glucose. Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus. A total of 150 patients of extra-pulmonary TB visiting tertiary care center in north India between September 2008 and December 2009 were included in the study.

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Optimal internal fixation for femoral neck fractures: multiple screws or sliding hip screws? In this paper, we address 3D object visualization and recognition with multi-wavelength digital holography. Here we describe the reproductive and developmental toxicity of TCDD in feral fish species and summarize how using the zebrafish model to investigate TCDD toxicity has enabled us to characterize the AHR signaling in fish and to better understand how dioxin-like chemicals induce toxicity. Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.

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Endocrine profile and semen characteristics in men with bilharzial hepatic fibrosis. Although the morphological, immunohistochemical, and imaging features of FNH-like nodules are well-known, their pathogenesis and role in hepatocarcinogenesis have not been studied in detail. DNA detection and genotypic identification of potentially human-pathogenic microsporidia from asymptomatic pet parrots in South Korea as a risk factor for zoonotic emergence. Monitoring growth rate in children reflects the state of health and nutrition of the individual as well as the state of health of a nation.

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In this study, we show that the P falciparum skeleton-binding protein 1 (PfSBP1) is required for transport of PfEMP1 to the P falciparum-infected erythrocyte surface. Comparative use of turkey and chicken wing brachial artery models for microvascular anastomosis training. Statistical benchmarks can be applied to results from quality assessment of mental health care.

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Little is known about the relative importance of self-image, physician attention to obesity, weight-loss program participation, exercise, self-motivation, and nutrition knowledge in the process of weight loss. Isolation and characterization of human urinary metabolites of meclomen. These artifacts are special metaphors for networks of repressed memories, in many respects like dream images. Transient glomerular hyperfiltration in the streptozotocin-diabetic Wistar Furth rat.

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Transcriptome analysis technologies are important systems-biology methods for the investigation and optimization of mammalian cell cultures concerning with regard to growth rates and productivity. Sixty-one stable, depigmented lesions were selected in 14 patients (9 women and 5 men), aged 16-29 years, of which 9, 3 and 2 had localized, generalized and segmental vitiligo, respectively.

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From the roots of Salvia prionitis a new tricyclic diterpene, saprirearine (1), a new anhydride-type compound, saprionide (2), a new 7,8-seco-abietane diterpene derivative, 7,8-seco-para-ferruginone (3), and two new 4,5-seco-5,10-friedo-abietane diterpenoids, 4-hydroxysaprorthoquinone (4) and 3-keto-4-hydroxysaprorthoquinone (5), were isolated. The complex interactions between the immune system and the central nervous system have been studied extensively in schizophrenia and depression. Percutaneous intentional extraluminal recanalisation of the femoropopliteal artery. The effect of different types of intrauterine devices on the risk of pelvic inflammatory disease.

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Active anaerobic ribonucleotide reductase from Escherichia coli contains an oxygen sensitive organic radical, proposed to reside on glycine-681 at the C-terminal end of the polypeptide chain. These findings replicated across 4 generations of participants--children, parents, grandparents, and their great-grandparents. The demographics and characteristics of the obstructing lesion were analyzed. While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention.

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Two patients with multiple hepatic carcinoid metastases experienced considerable symptomatic relief after the hepatic artery was embolised with fragments of absorbable gelatin sponge administered through a percutaneous arterial catheter. This research investigated and compared the effects of copper oxide (CuO) NP and dissolved copper, as copper chloride (CuCl2), on the sea anemone, Exaiptasia pallida. The protein expression was observed in the epithelial cells at all stages examined.

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Effect of in vivo desensitization to leukotriene B4 on eosinophil infiltration in response to C5a in guinea-pig skin. To examine lack of regeneration and present nutrient status, we analyzed soil nitrogen.

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QoL was assessed by the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) at baseline, post-treatment and six months follow-up. Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase. The complex machinery of intracellular signaling also has the potential to provide a wealth of novel drug discovery targets, from protein kinases, adaptor proteins, lipases, and cytoskeletal proteins, to nuclear effectors. Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor whose activation is linked to several physiological pathways including regulation of insulin sensitivity and control of inflammation. This in vitro assay might provide clues to the diagnostic evaluation of patients allergic to penicillins.

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Physicians and scientific research: slight decline of the numbers of physicians with a doctoral degree Basic problems of communicable disease control in the forces and ways to reorganize it

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Clinically, the revised cases were not inferior to the primary ones. CONSULTATION CLINIC: PAIN IN AN EDENTULOUS AREA MAY BE THE RESULT OF A DIFFICULT EXTRACTION. Effects of single applications of 12-O-tetradecanoylphorbol-13-acetate, mezerein, or ethylphenylpropiolate on DNA synthesis and polyamine levels in hairless mouse epidermis.

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A complex homeostatic mechanism, known as the unfolded protein response (UPR), has evolved to link the load of newly synthesized proteins with the capacity of the ER to mature them. A SYNONYM LEARNING TEST FOR USE WITH ELDERLY PSYCHIATRIC SUBJECTS: A VALIDATION STUDY. Interexaminer reliability studies: spanning a gap in medical research--Louisa Burns Memorial Lecture. Purification of a 24 kD parasitism-specific hemolymph protein from pharate pupae of the Caribbean fruit fly, Anastrepha suspensa.

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The combined use of natural ECM components and synthetic materials offers an attractive alternative to fabricate hydrogel-based tissue engineering scaffolds to study cell-matrix interactions in three-dimensions (3D). Quantifying sodium in the human wrist in vivo by using MR imaging. In particular, it is not known how patients with BNP elevation should be treated considering the fact that they have normal troponin levels and no clinical evidence of heart failure. Additionally, concentration of corticosterone (CORT) in plasma was estimated.

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Plasma concentrations of alfentanil following epidural administration. Fluorimetric determination of levoprotiline in human plasma after thin-layer chromatographic or high performance liquid chromatographic separation. Enriched glial cell fraction from rat brain as an immunogen and antigen

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Noninvasive assessment of children with chronic epilepsy is often imprecise and localization of seizure foci requires intracranial electroencephalographic monitoring. Preliminary evidence also indicates that meperidine interacts with alpha(2) adrenoceptors. Statistical models based on DNA spectral properties were developed and compared with a statistical model previously used with base modifications. By gathering the results that we had obtained on the pharmacokinetics of doxorubicin in 37 patients, we observed a correlation between the early clearance of this drug and the age of the patients, the youngest patients having the highest clearances.

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Enzymatic resistance of Escherichia coli to beta-lactams and clinical prevalence (Pediat Res 31: 492-495, 1992) who detected the presence of metabolites in maternal and fetal organs of pregnant C57B1/6J mice exposed to alcohol on GD 7 and/or GD 14. Nevertheless, data on the role of the cerebellum in modulation of normal reflex blinks are limited. Reported in this paper are three patients with malignant lymphoma.