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Although respiratory syncytial virus (RSV) causes severe lower respiratory tract infection in infants and adults at risk, no RSV vaccine is currently available. The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model.

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Research on the factors determining cellular clonogenic capacity following fractional irradiation by the method of computer simulation modelling The recombinant CT-1/TTC protein can be expressed and purified in BL21 (DE3) E.

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Septation in syringomyelia and its possible clinical significance. Responses of neurons to local or diffused illumination studied in the rat visual cortex revealed the leading role of inhibition in formation of the dynamic mosaic of neuronal ensembles. Then after a series of processes the inner ear tissue was cryostat sectioned. These results suggest that protein kinase C, calmodulin, and NO dependent cyclic guanosine monophosphate (GMP) dependent enzymes may contribute to the induction of convulsions. A novel peptide sequence, N117NQ-KIVNLKEKVAQLEA133, designated gamma 3, dose-dependently inhibited (IC50 approximately 20-40 micrograms/ml) binding of 125I-fibrinogen to endothelial cells or ICAM-1-expressing B lymphoblastoid Daudi cells.

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Electrogenic effect during active transport of lithium through the somatic membrane of mollusk neurons Gustatory otorrhoea: a rare case of congenital external ear salivary fistula. Recent graduates were contacted either at a reunion event (school A) or electronically from database records (school B and school C).

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In addition, bioinformatic analysis and experimental data indicate that miR-873 is involved in the regulation of the Hedgehog signaling, an essential pathway involved in craniofacial patterning and differentiation. Again, radiation therapy significantly decreased the local recurrence rate in the treated breast compared with observation alone. They have advanced mechanisms for capturing prey with their tongue, but have a primitive mechanism for hearing. CO2 Laser Assisted Uvulopalatoplasty (LAUP) is a safe and effective, ambulatory treatment for snoring, performed under local anesthesia. Before surgery, the mean intraocular pressure (IOP) was 25.1 (SD 3.2) mm Hg.

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Unexplained and prolonged perioperative hypotension after orthotopic liver transplantation: undiagnosed systemic mastocytosis. The clinical presentation, outcome, and US results were analyzed. The transmission of the short wavelength visible light decreased gradually with age. A new variant of spinal muscular atrophy (S.M.A.), characterised by adolescent onset, gross hypertrophy of calves, and a slowly progressive clinical course, was found in 5 patients, 3 of them in a series of 102 cases being studied in North-East England. The as-obtained CeO2 nanoparticles were closely contacted with graphene, which can enhance the synergistic effect between graphene and CeO2.

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Semantic priming paradigms show utility in assessing the role of deficits in semantic memory network access in the pathology of schizophrenia. The partial purification of the formate dehydrogenase from cell-free extracts of Methanobacterium formicicum decreased the rate of coenzyme F420 reduction 175-fold relative to the rate of methyl viologen reduction. Tuberculous osteomyelitis of the bone flap following craniotomy.

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The purpose of our study was to identify the preoperative factors predictive of satisfaction following well-performed TKA. The first group included 103 pregnant women with signs of a thrombosis, thrombophlebitis, varicose veins expansion of lower limbs etc. An analysis was undertaken of consultation rates in 226 UK general practices contributing to the General Practice Research Database.

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10 personnel had their temperature recorded by both devices at the same time by a single operator every day. Charts from 33 consecutive patients selected for surgery, who underwent preoperative SPET/CT and magnetic resonance imaging (MRI), were reviewed. Echocardiography demonstrated secundum atrial septal defect (ASD) with marked right sided dilatation, indicating significant left to right intracardiac shunting. The presence of hemoglobin H (beta 4), resulting from a deficiency of alpha-globin chain synthesis, was observed as an acquired characteristic in the red cells of five elderly patients with myeloproliferative disorders or preleukemia. The primary outcome measures were the mean changes in BCVA between the two treatment groups, and the proportion of eyes gaining 1 and 3 lines at the end of the follow-up.

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Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity. Rhabdomyolysis associated with fenofibrate monotherapy in a patient with chronic myelogenous leukemia. The possibility that resistance to infection is associated with T lymphocyte responses classed as Th-2 type will be investigated by assessing reactivities to defined antigens of S. pH sensitive organic-inorganic layered nanomaterials by self-assembly of indigocarmine between the inorganic layers.

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A new study shows that, when rats discriminate different textures using their whiskers, both spike-rate and spike-timing information in somatosensory cortex contribute to their perceptual decisions. Conversely, participants in the third and fourth quartiles of fast speed were more likely to develop SCD. The latest advances in exercise echocardiography, including utilization of tissue Doppler imaging and harmonic imaging, make noninvasive evaluation of both conventional and alternative cardiac causes of exertional dyspnea possible.

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Genetic variants of the interleukin-18 promoter region (-607) influence the course of necrotising enterocolitis in very low birth weight neonates. In stenotic lesions of the extracranial carotid arteries, the presence of intraplaque hemorrhage or thrombosed ulceration is considered to pose an additional risk.

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No central nervous system anomalies were detected in the affected fetus, who presented with large polycystic kidneys and polydactyly. Physicians treated trauma-related soft tissue infections, particularly when the initial Gram stain shows many polymorphonuclear leukocytes and gram-negative bacilli, must consider the possibility of an Aeromonas infection even if the injury occurred in a nonaquatic environment. Aetiology and pathogenesis of hormonal and metabolic disorders in HIV infection. Sertoli-stromal cell tumor of the right ovary: radiological-pathological correlation. Level and predictors of agreement between patients and their dentists concerning need for replacement of teeth at the time of extraction.

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The novel findings of this study are that multiple IAPs are concomitantly expressed in breast cancers, and that, in combination with clinically relevant Her2 treatments, IAP antagonists promote apoptosis and reduce the cell turnover index of breast cancers. Retinal degenerative disease has limited therapeutic options and the possibility of stem cell-mediated regenerative treatments is being actively explored for these blinding retinal conditions. Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation--United States, 2003-2005. Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses.

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Refractory torticollis: an uncommon complication of adenotonsillectomy. Data analysis revealed 2 somatotopic body representations on the lateral operculum in areas OP 1 and OP 4.

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Using colonoscopy alone however, a large proportion of people still have cancer anxieties after being screened. Communication is complicated by multiple languages, time pressure, and inadequate information systems. Mutagenesis of the lipA promoter region indicated that most transcription depends on LipR binding to the proximal half-site of the LipR box in close proximity to the -35 region of the promoter.

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Herein, we investigated the preventive effect of vitamin E on 4-nitroquinoline 1-oxide (4NQO)-induced oxidative damage on pulmonary nuclei and lung tumorigenesis in mice. Bioinformatic analyses to impute the biological significance of these miRNAs identified 36 predicted gene targets from those regulated by 4-OHT in MCF-7 cells. CNTF and LIF treatments down-regulated CNTF binding to sympathetic neurons and EW-1 cells, suggesting that heterologous ligands can regulate CNTF receptor levels, which may in turn modulate the efficacy of CNTF in vitro and in vivo. Study of activity in segmental pathways can help in understanding the pathophysiology of clinical disorders due to basal ganglia damage.

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ON CHARACTERISTICS OF EVOKED POTENTIALS DURING EXTINCTION OF THE ORIENTING REACTION IN DOGS Dietary protein modifies hepatic gene expression associated with oxidative stress responsiveness in growing pigs. In this context, the in vivo mouse comet assay was performed on both isolated kidney and colon cells in order to demonstrate a possible organospecific genotoxicity after oral administration of AE. There may be cultural ethnic and age-related differences in social determinants of health. However, while there has been significant effort to design the next generation of antimalarial drugs, one area that is underrepresented in the current antimalarial pharmacopeia is that of transmission blocking drugs directed at late-stage gametocytes.

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Current medical knowledge has provided us with a wide range of possibilities of treating chronic wounds. We investigated a large series of consecutive breast reductions to study important factors that impact outcomes. Reliability of rectal epithelial kinetic patterns as an intermediate biomarker of colon cancer. Acute myocardial ischemia directly modulates the expression of brain natriuretic peptide at the transcriptional and translational levels via inflammatory cytokines.

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Very little is known of the fetal requirement for creatine and how this may change with advancing pregnancy and into the early neonatal period. 1alpha,25-dihydroxyvitamin D3 downregulates CYP27B1 and induces CYP24A1 in colon cells. The diagnosis was confirmed in the two cases by the histologic examination. Unilateral stellate ganglion block produces bidirectional changes in tissue oxygen tension of the mental nerve in rabbits. The questionnaire inquired about port-related aspects of everyday life and the use of a central venous access port device for chemotherapy and supportive cancer care.

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The removal of seven drugs with different molecular weights and protein binding characteristics was assessed. Also numerical simulations for solutions and their stability are presented. Altered biochemical parameters in saliva of pediatric attention deficit hyperactivity disorder. 11-cis-ARAT activity remained unchanged when assayed in the presence of all-trans-retinol, suggesting a distinct catalytic activity from that of all-trans-ARAT. The three antigens evaluated (Sp1, Sp2 and Sp3) were highly adsorbed by aluminum hydroxide adjuvant, but not adsorbed by aluminum phosphate adjuvant.

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The anatomic basis of utilisation behaviour: a shift from frontal-parietal to intra-frontal mechanisms. This observed inactivity of the psi zeta gene is unlikely to be caused by mRNA instability since hybrid alpha/psi zeta gene constructs produce high levels of mRNA in Cos7 cell transient expression assays. Linkage between the beta B2 and beta B3 crystallin genes in man and rat: a remnant of an ancient beta-crystallin gene cluster. Applications of selective neutrality tests to molecular ecology.

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Vaccination with the modified peptide analogue can then be used to induce an immune response to the wild-type epitope. Overexpression studies indicate that nuclear eIF4E promotes the transport of cyclin D1 mRNA from the nucleus to the cytoplasm and that PML is a key negative regulator of this function. ANTIGENIC TRANSFORMATION IN RELATION TO NUTRITIONAL CONDITIONS AND THE INTERAUTOGAMOUS CYCLE IN PARAMECIUM AURELIA. Limitations of ventriculocisternal perfusion for determining brain interstitial fluid composition. Multiple nuclear factors bind to novel positive and negative regulatory elements upstream of the human MHC class I gene HLA-A11.

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Levorphanol is also an N-methyl-D-aspartate (NMDA) receptor antagonist. Control systems analysis is proposed as a method for understanding the pathophysiology of oculomotor imbalance, thereby permitting better differential diagnosis and more specific treatment. Using an efficient intersection algorithm in the nested tetrahedral environments previously developed by the authors, we demonstrate fully adaptive tomography using a posteriori error estimates. The separation according to molecular microstructure is found to be based on the cooperative effects of the normal and thermal diffusion coefficients.

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Comparison between Crithidia luciliae kinetoplast immunofluorescence test and Farr technique. ORN lesioned animals receiving injections of TGF-alpha during recovery were found to display enhanced conditioned responding to an olfactory stimulus compared to untreated subjects. Fractures of the proximal ulna present unique challenges to the surgeon because of the complexity of the elbow joint. Feeding breastmilk to premature infants decreases morbidity but is often limited owing to an insufficient milk supply and delayed attainment of lactogenesis stage II.

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Menopausal hormonal changes are relevant to the causes of sexual dysfunction during reproductive aging. There was clear evidence of diffusion when fixation was delayed for as little as 1 h, resulting in focal labelling of cells which did not contain antigen in rapidly fixed tissues.

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In this study, we track caudal vertebral growth in a mixed longitudinal sample of white-fronted and brown capuchin monkeys (Cebus albifrons and Cebus apella). Bone mineral density and surgical treatment of primary hyperparathyroidism. Improvements in the slide magazine and slide autochanger have quadrupled the number of slides that may be loaded into the machine at one time while increasing the speed of operation. The mice were sacrificed with an interval of 24 hours each, starting in the next day after inoculation.

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We found no RCTs for physical movement, multidisciplinary treatment, or alternative medicine. Effect of the substrate and catalyst chirality on the diastereoselective epoxidation of limonene using Jacobsen-type catalysts.

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Symptomatic refractures after vertebroplasty in patients with steroid-induced osteoporosis. A high cognitive reserve capacity, however, might delay the onset of deterioration. DOM-potentiated slices show decreased autophosphorylated CaMKII (p-Thr286), an effect that is also dependent on the activity of CaMKII and PKA. Future controlled trials are required to confirm the efficacy of this nomogram. Associations between components and other indicators of maturity are apparent, indicating that serial fat patterns are controlled to some degree by influences affecting other pubescent events.

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A GH dose of 0.5-1.0 IU/m2/day (4-9 micro g/kg/day) stimulated bone remodelling and increased BMD over 12 months in patients with severe GHDA, irrespective of gender. Purification and characterization of a high molecular weight eosinophil chemotactic factor from Schistosoma japonicum eggs. In case of inoperability the possibilities of palliative surgery should be examined: palliative resection, quantitative tumour reduction, different bypassing procedures in the G.I-tract, amputation, exarticulatoan. Levels of anxiety were measured preoperatively along with other physiologic, psychologic, and immunologic modalities. A secondary objective was to determine clinical and radiological risk factors for the PHMM.

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Diabetes mellitus is a metabolic endocrine disorder that affects many systems, the gastrointestinal system often being among the affected systems. In addition, concentrations were determined in five lower trophic level fish species. Also 2-AG levels were significantly elevated after long alcohol exposure, and an additional increase was found after limited access drinking in PFC. The effect of unintentional overdoses of pilocarpine on pulmonary surfactant in mice

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Left ventricular dimensions remained unchanged in all except one study. Monoaminergic regulation of neuroendocrine function and its modification by cocaine. In patient in the 33rd week of pregnancy with the diagnosed cervical carcinoma of the 2nd degree, diagnosed on the basis of histopathological examination, Caesarean section and Meigs operation were performed.

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Emphasis should be put on these patients with high risk factors and preventive strategies should be taken to prevent their progression. SPECIFICATIONS FOR THE IDENTITY AND PURITY OF FOOD ADDITIVES AND THEIR TOXICOLOGICAL EVALUATION: FOOD COLOURS AND SOME ANTIMICROBIALS AND ANTIOXIDANTS. Several microbial pathogens can modulate the host apoptotic response to infection, which may contribute to immune evasion. The ability of rat transplantable lymphosarcoma cells to synthesize immunoglobulins. In this case-referent investigation on the possibility of occupational exposures being related to the lung cancer excess, cases and referents were selected from butchers and slaughterhouse workers registered in the Swedish national census of 1960.