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Topiramate comes as a tablet, a sprinkle capsule (capsule that contains small beads of medication that can be sprinkled on food), and an extended-release (long-acting) capsule to take by mouth. The tablets and sprinkle capsules are usually taken with or without food once or twice a day. The extended-release capsules are usually taken with or without food once a day. Take topiramate at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take topiramate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

There is another medication with a name similar to the brand name for topiramate. You should be sure that you receive topiramate and not the similar medication each time you fill your prescription. Be sure that the prescription your doctor gives you is clear and easy to read. Talk to your pharmacist to be sure that you are given topiramate. If you think you were given the wrong medication, talk to your pharmacist. Do not take any medication unless you are certain it is the medication that your doctor prescribed.

Topiramate tablets have a bitter taste so you should swallow them whole. It is especially important that you not take topiramate tablets that have been broken for any length of time because tablets that are broken may lose their effectiveness over time.

The sprinkle and extended-release capsules (Qudexy XR brand only) may be swallowed whole or opened and poured over soft food. Swallow extended-release capsules (Trokendi XR brand only) whole; do not split, chew, or sprinkle on food.

To take the sprinkle capsules or extended-release capsules (Qudexy XR brand only) with food, follow these steps:

  1. Prepare a teaspoonful of soft food such as applesauce, custard, ice cream, oatmeal, pudding, or yogurt.
  2. Hold the capsule upright over the food.
  3. Twist off the top of the capsule and pour the entire contents onto the spoonful of food.
  4. Swallow the entire mixture immediately without chewing.
  5. Drink fluids right after swallowing to wash down the mixture and to be sure that you swallow all of it.

Your doctor will probably start you on a low dose of topiramate and gradually increase your dose, not more than once every week.

Topiramate may control your seizures or migraines but will not cure your condition. Continue to take topiramate even if you feel well. Do not stop taking topiramate without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking topiramate, you may have severe seizures, even if you have not had seizures in the past. Your doctor will probably decrease your dose gradually.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with topiramate and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( or the manufacturer's website to obtain the Medication Guide.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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After 1 h of reperfusion, a further accumulation of ammonia concentration was observed. Isoelectric focusing purity criteria and 1H NMR detectable spectroscopic heterogeneity in the major isolated monomer hemoglobins from Glycera dibranchiata. A 42-year-old male with Marfan syndrome, who had undergone aortic root and total arch replacement for type-A acute aortic dissection at the age of 40, underwent descending aorta replacement with woven Dacron (Vascutek Ltd., Renfrewshire, Scotland) because of pseudoaneurysm at the site of the distal anastomosis and an enlarged pseudolumen of the dissecting descending aorta. The enzyme was found to be pH-tolerant when stored at 20 degrees C, pH 6.3-10.3 (100 mM Briton-Robson buffer) as the half-life (t(1/2)) was more than 240 h when p-NPB was used as the substrate.

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The decay-corrected tritium activity of the water in which the salt cedar grew closely agrees with the organically bound tritium activity in its annual rings. Caution is required to avoid overlooking the patent urachus, and intestinal lengthening procedures based on the vitelline artery become an important consideration. By various examples it can be illustrated that not only a lack of services but also an overuse of medical care may be hazardous and reduce quality in medicine. Whispering-gallery modes resonances of submicron wall thickness capillaries exhibit very large wavelength shifts as a function of the refractive index of the medium that fills the inside. To assess whether maternal plasma antioxidant levels in mid-pregnancy are associated with small-for-gestational-age (SGA) birth.

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All forms of sedation and anesthesia should be administered in an environment of trust, empathy, and competence in both the behavioral and clinical sciences. Mineral density of trabecular bone at the metaphyses of right tibiae was measured by peripheral quantitative computed tomography (pQCT) in ovariectomized rats. Activity of acid protease in subcellular fractions of dog brain with intracysternal administration of antibodies Except for prepro-VIP(111-122) which was found to be approximately 3 x higher concentrated in the SCN than in the cerebral cortex, the other immunoreactivities were found in almost similar relative concentrations in the two tissues.

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The extracting solution seems to determine the antigenic profile of olive pollen extracts. Between August 1996 and June 2010, we operated on 209 patients with a preoperative diagnosis of carcinoma of the gallbladder and common bile duct. A postal questionnaire was used in a survey of dysuria in women aged 20-54 years in four London general practices. There has been comparatively little consideration of the impact that the changes to undergraduate curricula might have on postgraduate academic performance.

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Selective inhibition of the liver phosphorylase isoform could minimize adverse effects in other tissues. Analysis of the sample by liquid chromatography coupled with evaporative light scattering detection resulted in an elution profile consisting of a series of peak clusters. Here we first measure the reflectivity of such a film down to 5 cm(-1), by also using coherent synchrotron radiation. Stimulation of neutrophil oxygen-dependent metabolism by human leukocytic pyrogen. Herein we describe an efficient method for the synthesis of thioether-based hydrogen bond surrogate (teHBS) helices.

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Brain delivery of biotin bound to a conjugate of neutral avidin and cationized human albumin. Coordination patterns of children in the DCD group were less stable in all three limb combinations compared with controls. Studies on human hyperplastic prostates maintained in organ culture. The accumulation of PUFAs in phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine correlated with an induced lysophosphatidic acid acyltransferase (LPAAT)3 mRNA expression, increased microsomal LPAAT3 activity, and shift of LPAAT specificity to PUFA-coenzyme A.

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Color duplex ultrasound was used to measure the peak systolic velocity and systolic rise time in the deep penile arteries in 22 impotent men following papaverine stimulation. As a clinical consequence of the results, an extension of the interdisciplinary concepts within the sense of an orthopedic examination can be considered for patients undergoing a combined orthodontic-operative therapy.

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Semi-structured interviews were carried out with 12 health professionals with current/recent stroke rehabilitation experience in Kuwait, followed by thematic analysis of the verbatim transcripts. Luther Emmett Holt, a leading pediatrician, encouraged three other doctors to investigate the condition. An integrated approach with a combination of technologies from the fields of engineering, biomaterials science, cell biology, physics, and medicine is required to address these complexities. Light and electron microscopic examination of biopsied sural nerve disclosed a moderate decrease in large myelinated fibers, but not in either small myelinated or unmyelinated fibers. Evaluation of the chemokine variation in tears of contact lens wearers

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This method for detection of sentinel lymph nodes in patients with endometrial cancer is promising, fast and easy to implement, but need to conduct additional studies to become part of the standard for the surgical treatment of endometrial cancer Point Aa does not reflect bladder neck mobility accurately as measured by the Q-tip angle after surgical restoration of the pelvic anatomy. One protein is present in 12 day female germ cells and nongerminal gonadal preparations, but disappears by day 14. ICGA suggests that functional outcomes after intravitreal ranibizumab is related to CMT reduction rather than CNV regression. New diagnostic approaches based on molecular methods have been developed for sensitive detection of CPV in clinical samples and rapid characterisation of the viral type.

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Despite evidence that members of this protein family may be targeted by arginine methylation, this has yet to be experimentally addressed. Results suggest that assessing the epigenetic aspects of breast tumours could strongly improve our understanding of the biology and heterogeneity of breast cancers. Distant metastasis was common in lung cancer, especially patients with bone marrow metastasis had poor prognosis and there were few effective methods. Dietary iron deficiency decreases serum osteocalcin concentration and bone mineral density in rats. Application of adaptive digital signal processing to speech enhancement for the hearing impaired.

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Both mRNA and protein levels of Oat1, Oat3 and Bcrp were significantly decreased in folic acid-induced acute renal failure rats. Road accidents are the main cause of thoracic injury, with accidents involving pedestrians and shootings being associated with a greater death rate. We report a pediatric patient of Lyme disease in Taiwan, confirmed by laboratory tests. Complex surgery does not seem to affect survival when accounting for other confounding influences, particularly RD. The Scandinavian Candesartan Acute Stroke Trial (SCAST) found no benefits of blood pressure-lowering treatment with candesartan in acute stroke.

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We investigated the role of human FLASH by using an inducible FLASH knockdown system in the presence or absence of various mutant forms of mouse FLASH. Translation invariance in the responses to faces of single neurons in the temporal visual cortical areas of the alert macaque.

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Ultrastructural studies failed to reveal lysosomal abnormalities. To identify the amino acid regions involved in these properties, we compared the characteristics of RCE1, EGL3, and three chimeric endoglucanases, in which each of the three regions of the catalytic domain of EGL3 was replaced by the corresponding region of the catalytic domain of RCE1. There was a rapid disappearing of discocytes I correlated with time of storage. DYNAMICS OF ELECTRICAL HAZARDS OF PARTICULAR CONCERN TO OPERATING-ROOM PERSONNEL. These results argue strongly against a one-carrier model for transport of folate compounds.

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We applied a genomic approach in the identification of genes required for the biosynthesis of different polysaccharides in Rhizobium leguminosarum bv. The addition compound quickly decomposed above pH 6 to give back the parent compound and, thus, acted as a I prodrug. According to cross-species reaction, we confirm the heterogeneity of ICA in a large series of type I diabetic patients, ICAs that cross-reacted with mouse pancreas being more frequent than ICAs without cross-species reactivity.

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Repression of rRNA synthesis during slug reconstruction in Dictyostelium discoideum. Dental caries experience and defects of dental enamel among 12-year-old children in north London, Edinburgh, Glasgow and Dublin. DBR, Sub-wavelength grating, and Photonic crystal slab Fabry-Perot cavity design using phase analysis by FDTD. Period-amplitude analysis was used to measure the number of waves per unit time (wave incidence) and wave amplitude for 19 wavelength categories in the lateral cortical electroencephalogram (EEG) of five intact and four suprachiasmatic nuclei-lesioned rats during NREM sleep, waking, and paradoxical sleep (PS) over a period of 24 h. So it is concluded that in order to remove any bias, normal hospital controls or controls selected from multiple cancers should be taken to study the risk factors involved in cervical carcinogenesis.

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Cases of spontaneous neoplasms in amphibia are updated and the rarity of spontaneous neoplasia is considered as a result of either inadequate research or the regenerative capacity of these animals. This study provides new insights into the regulation of VP8 phosphorylation and suggests a novel, phosphorylation-dependent function for VP8 in the life cycle of BoHV-1, which is important in view of the fact that VP8 is essential for virus replication in vivo. To date, little information is available regarding the healthcare utilisation patterns in the last year of life in New Zealand. Findings provide no evidence that combining smoking treatment and behavioral weight control produces any harm and significant evidence of short-term benefit for both abstinence and weight control. Significant differences in the drug release profiles were observed between the formulations containing the free drug base and those with the hydrochloride salt as a result of an altered microenvironmental pH.

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We present an additional case of lingual intestinal-type adenocarcinoma with mucinous features that occurred in association with cervical node metastasis and discuss the clinicopathologic features and histogenetic aspects of this rare entity. However, the donor cells were fully forced by the recipient reserve cells, type A0 spermatogonia, within eight to bromocriptine dose for milk suppression list nine months. Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Telomeres in the absence of functional telomerase shorten, became unprotected, and are eventually recognized by the cell repair system as double stranded breaks.

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Pathogenesis of NSAID-induced gastric mucosal damage--search for primary events and role of COX inhibition Hepatitis B virus lipcor review strains with mutations in the core promoter in patients with fulminant hepatitis. In a randomized controlled clinical crossover study, behavioral reactions to hot iron branding and microchip transponder injection were scored by 4 observers. Dietary data were collected using a Willett Semi-Quantitative Food-Frequency Questionnaire.

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The purpose of this study was to determine the acyclovir price in mercury drug price location, nature, and occurrence of incidental maxillofacial findings on cone beam computed tomography (CBCT) scans performed for maxillofacial diagnostic purposes. Plasma-exchange combined with immunosuppressive therapy in myasthenia gravis. Awareness of antibiotic prescribing and resistance in primary dental care.

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Proteasome activity, concentrations of plasma lipids and levels review detergent ultracon of peroxidation were determined. The nondestructive detection of early fatigue damage states is of high importance for safety in aircraft, automobiles, railways, nuclear energy industries and chemical industries. The main purpose of this study is to find a right representation and matching of action video volumes for categorization. Despite extensive investigation of the structure, the cellular basis of the transduction mechanism remains poorly understood. We assessed the prevalence of GI complaints in patients on either haemodialysis (HD), peritoneal dialysis (PD), or in the pre-dialysis stage.